Mushawwir Taiyeb, Hartati Hartati, Arwansyah Arwansyah, Dahlia, Abd. Muis, A. Mu'nisa, Abdur Rahman Arif, Liza Md Salleh
Hyperglycemia is one of the causes of diabetes mellitus. One example of a plant used as an anti-hyperglycemic and anti-diabetic herbal medicine is the mahogany plant (Swietenia mahagoni). Drugs in nanoemulsion dosages must be developed to increase oral bioavailability and drug solubility from herbal plant extracts. So, research was carried out to determine the formulation and optimization of nanoemulsion from mahogany seed extract (Swietenia mahagoni) and its effect on reducing blood glucose levels in mice (Mus musculus L.). Based on research that has been carried out, the nanoemulsion formula for mahogany seed extract is characterized by a transmittance percentage of 84.7 % and a particle size of 12.21 nm. Administration of mahogany seed extract and nanoemulsion formulation of mahogany seed extract (Swietenia mahagoni) can reduce blood glucose levels in hyperglycemic mice (Mus musculus L.). Further, a computational analysis using the molecular docking approach was carried out to analyze the molecular interaction between the main components of mahogany seed (glycidyl oleate and glycidyl palmitoleate) and alpha-glucosidase. The outcome suggested that these substances are bonded to the alpha-glucosidase catalytic sites by hydrogen bonding and hydrophobic interactions and are stable during MD simulation, suggesting that the primary components of mahogany seed may become potential alpha-glucosidase inhibitors to treat diabetes. © 2024 The Authors
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Makassar, Indonesia; Department of Chemistry Education, Faculty of Teacher Training and Education, Tadulako University, Palu, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Indonesia; Department of Bioprocess and Polymer Engineering, Faculty of Chemical and Engineering, Universiti Teknologi Malaysia, Malaysia
