Tomoki Nakamura, Takuma Suzuki, Nanang Rudianto Ariefta, Takuya Koseki, Takako Aboshi, Tetsuya Murayama, Ari Widiyantoro, Rikhsan Kurniatuhadi, Abdul Malik, Suwardi Annas, Desi Harneti, Rani Maharani, Unang Supratman, Junpei Abe, Naoaki Kurisawa, Ken-ich Kimura, Yoshihito Shiono
Fractionation of ethyl acetate extract obtained by culturing the endophytic fungus Pseudocosmospora sp. Bm-1-1 resulted in the isolation of four new meroterpenoids, cosmosporin A (1), 6-carboxy-cosmosporin A (2), rel-(6aS,10aR)-Δ 9 -tetrahydrocannabiorcolic acid B (3) and 8′-hydroxy-cannabiorcichromenic acid (4), in addition to four known compounds 5–8. Structures were elucidated by spectral analysis, as well as by directly comparing the spectral data of new compounds with those of known compounds. Cannabiorcichromenic acid (5), decarboxy-cannabiorcichromenic acid (6), and rel-(6aS,10aR)-decarboxy-Δ 9 -tetrahydrocannabiorcolic acid B (8) restored growth of a Saccharomyces cerevisiae mutant strain involving Ca 2+ signal transduction. Furthermore, compounds 3 and 8 had cytotoxic activity against HL60 cells (3: IC 50 = 24.1 μM and 8: IC 50 1.6 μM). © 2019 Phytochemical Society of Europe
Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, 997-8555, Yamagata, Japan; The United Graduate School of Agricultural Sciences, Iwate University, Morioka, 020-8550, Iwate, Japan; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Tanjungpura, Pontianak, 78124, Indonesia; Department of Geography, Faculty of Mathematics and Natural Sciences Universitas Negeri Makassar, Makassar, 90224, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, 45363, Sumedang, Indonesia; Graduate School of Arts and Sciences, Graduate Course in Biological Chemistry and Food Sciences, Iwate University, Morioka, 020-8550, Iwate, Japan
