Chaerul Fadly Mochtar, Agil Mutiara Putri, Alis Tanya Qiranasiva Miraj, Annisa Fitriani, Muhammad Dony Pratama, Amalia Salsabila Usman, Suriati M.Si. M. Kes
Objective: This study aimed to determine the antioxidant, antibacterial, and anti-inflammatory activities of ethanol extracts from red Dadap flowers (Erythrina crista-galli L). In addition to formulate the extract into a moisturizing gel preparation of good physical quality. Material and Methods: Antioxidant activity was determined using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity assay. Antibacterial activity was evaluated using the disc diffusion method. Anti-inflammatory activity was evaluated using carrageenan-induced paw edema in mice in vivo. Additionally, in silico studies were performed and the physical quality of the extract-gel formulation was evaluated. Results: Antioxidant testing resulted in a half-maximal inhibitory concentration (IC50) value of 79.1 ppm and an AAI value of 0.4. Antibacterial testing obtained the largest inhibition zone, with an average of 9.0 mm. Anti-inflammatory testing obtained the greatest anti-inflammatory effect at a dose of 300 mg/kg body weight in mice, with a percentage of inflammation inhibition that reached 59.32%. In silico testing, the smallest binding affinity values were obtained: respectively, at-10.3,-12.0, and-10.2 kcal/mol, by the specific compound Cyanidin-3-O-glucoside. Physical quality evaluation obtained values that are in accordance with the Indonesian National Standard. Conclusion: Ethanol extract of red Dadap flower (Erythrina crista-galli L.) has antioxidant and antibacterial activity in the weak category; however, in contrast it has anti-inflammatory activity in the strong category. In silico also obtained good activity in accordance with the results of in vivo testing. Erythrina crista-galli L. flower extract can be formulated into a moisturizer gel, this can be seen from the results of good physical stability. © 2025 JHSMR. Hosted by Prince of Songkla University. All rights reserved.
Faculty of Sport and Health Sciences, Universitas Negeri Makassar, Sulawesi Selatan, 90222, Indonesia; Indonesian Biofilm Research Collaboration Centre, Farmako, Sekip Utara, Sleman, Yogyakarta, 55281, Indonesia; Faculty of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Kalimantan Timur, Samarinda, 75124, Indonesia; Faculty of Public Health, Universitas Indonesia Timur, Sulawesi Selatan, 90222, Indonesia
