Hartati Hartati, Hartono Hartono, Hilda Karim, Suriati Eka Putri, Sahribulan Sahribulan, Kusdianawati Kusdianawati, Satria Putra Jaya Negera
This study aims to produce a Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulation of containing a combination of mahogany seed and moringa leaf extracts with antidiabetic activity. The research was conducted by extracting mahogany seeds via Soxhlet extraction and moringa leaves via maceration. SNEDDS was prepared by mixing mahogany seed and moringa leaf extracts with surfactant (Tween 80) and cosurfactant (PEG 400), followed by characterization using a Particle Size Analyzer (PSA). Furthermore, the antidiabetic activity test of SNEDDS formulation of mahogany seed extract and moringa leaf was conducted in vivo using male mice. The antidiabetic activity test in mice was conducted by administering the SNEDDS formulation via the oral route. Thirty-five male mice (Mus musculus L.) were induced with hyperglycemia using alloxan and served as the study's experimental animals. All mice were divided into 7 groups, namely positive control group, negative control group, mahogany seed extract SNEDDS group (SM), moringa leaf SNEDDS (SO). The results show the SNEDDS formula group of mahogany seed extract and moringa leaf which has the best characterisation of the test results. The SNEDDS formulation treatment had an average percentage of decrease in blood sugar levels which was quite high in the SM and SO formula with a ratio of 1:1 of 33.36±7.14, this formula was slightly higher than the ratio of 1:2 of 32.26±6.95. ANOVA test results show a significance value of 0.01 (p<0.05) which means there is a difference in influence between treatments. These findings suggest that the SNEDDS formulation containing mahogany seed and moringa leaf extracts demonstrates significant antidiabetic potential. ©2025 The authors.
Department of Biology, Universitas Negeri Makassar, Makassar, 90244, Indonesia; Department of Chemistry, Universitas Negeri Makassar, Makassar, 90244, Indonesia
