Harningsih Karim, Arief Azis, Ananda Ramadani, Anita Anita, Ahyar Ahmad, Hasnah Natsir, Paulina Taba, Suriati Eka Putri, Sarlan Sarlan, Siti Halimah Larekeng, Rizal Irfandi
Unique and varied bioactive compounds produced by the ocean have drawn attention and served as a focus for creating antibacterial and anti-inflammatory agents. As part of the approach for locating these research sources, databases such as PubMed, Science Direct, MDPI, Google Scholar, Springer Link, Web of Science, Scopus, and Wiley Online Library were used to identify completed studies. Numerous intriguing bioactive compounds have so far been isolated from marine bacteria. A crucial resource in the ongoing search for novel peptides, proteins, lipids, nucleosides, enzymes, alkaloids, polyketides, and terpenoids is the diversity of marine bacterium strains. This review summarizes several bacterial intracellular and extracellular bioactive compounds that have been applied as antibacterial and anti-inflammatory agents in 2016–2024, which we present in the form of structures, species sources, and evaluations of these compounds' antibacterial and anti-inflammatory activities. Therefore, this review article can be used as a recommendation for utilizing biomaterials from marine bacteria that are promising in the future for industrial-scale production of antibacterial and anti-inflammatory agents. © 2025, Gadjah Mada University. All rights reserved.
Department of Pharmacy, School of Pharmacy YAMASI, Jl. Mapala 2 Blok D5 No. 10, Makassar, 90222, Indonesia; Doctoral Program, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, Indonesia; Medical Laboratory Technology, Polytechnic Muhammadiyah Makassar, Jl. Dr. Ratulangi No. 101, Makassar, 90132, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, Indonesia; Research and Development Center for Biopolymers and Bioproducts, LPPM, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Makassar, Jl. Daeng Tata, Makassar, 90244, Indonesia; Faculty of Forestry, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, Indonesia; Research Collaboration Center for KARST Microbes BRIN-LPPM, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, Indonesia; KARST Bioprospecting and Society Research Group, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, Indonesia
